Many mycotoxins have carcinogenic, mutagenic, hepatotoxic, nephrotoxic and neurotoxic effects and can impact hormone balance, cause neurological symptoms, breathing issues, recurrent sinus issues, rashes, depression, affect memory, vision, drive fatigue, anxiety, insomnia and more. Moulds do not make mycotoxins specifically to make people sick, but as a protective mechanism to keep competitive moulds out of the environment. Mycotoxins have toxic properties and are responsible for the musty odours associated with damp indoor spaces. Many mycotoxin exposures occur through food ingestion (via improper storage or via animals eaten) or airborne exposure. Mycotoxins are metabolites produced by fungi such as mould, which can overgrow in buildings, vehicles, and foodstuffs. Mycotoxins and microbial volatile organic compounds (MVOCs) are some of the most prevalent toxins in the environment. The Organic Acids Test also includes markers for vitamin and mineral levels, oxidative stress, neurotransmitter levels, and is the only organic acids test to include markers for oxalates, which are highly correlated with many chronic illnesses.Ĭontact Us To Find Out More Or Order A Test Great Plains Mould Exposure Profile (Mycotox) Abnormally high levels of these microorganisms can trigger or drive behavioural issues, hyperactivity, movement disorders, fatigue and immune function, and pinpoint issues with weight loss, mood disorders, pain and more.
The Organic Acids Test (OAT) offers a comprehensive metabolic snapshot of overall health with 76 markers and provides an accurate evaluation of intestinal yeast and bacteria. Some of these bacterial byproducts from the intestine enter the blood stream and may alter the metabolism of neurotransmitters such as dopamine One of the most important uses of the organic acids test is as an indicator of dysbiosis, an abnormal overgrowth of yeast and bacteria in the intestinal tract. Many organic acids can directly or indirectly indicate deficiencies of critical vitamins and minerals. Others may impact mitochondrial function. For example, toxic amounts of medications and other toxic chemicals can use up a key molecule, glutathione, that helps the body detoxify, leading to the overproduction of the organic acid pyroglutamic acid. Many other non-genetic factors can also alter human metabolism.
Organic acidaemias are disorders of intermediary metabolism that lead to the accumulation of toxic compounds that disturb multiple intracellular biochemical pathways including glucose catabolism (glycolysis), glucose synthesis (gluconeogenesis), amino acid and ammonia metabolism, purine and pyrimidine metabolism, and fat metabolism.Ĭlinical presentations of organic acidaemias vary widely and may include failure to thrive, intellectual development disorders, hypo- or hyperglycaemia, encephalopathy, lethargy, hyperactivity, seizures, dermatitis and other skin issues, dysmorphic facial features, microcephaly, macrocephaly, anaemia, oxalate issues, immune deficiency with frequent infections, ketosis and/or lactic acidosis, hearing, speech, or visual impairment, peripheral neuropathy, sudden cardiorespiratory arrest, and more.
Many genetic disorders are caused by the production of an inefficient enzyme that reacts at a slower than usual rate, resulting in an accumulation of a metabolic intermediates. Over 1,000 different organic acids have been detected in urine. Organic acids are chemical compounds excreted in urine and are the products of metabolism. It provides an accurate evaluation of intestinal yeast and bacteria, oxalates, mitochondrial activity and includes markers for vitamin and mineral levels, oxidative stress and neurotransmitter levels. The Organic Acids Test (OAT) offers a comprehensive metabolic snapshot of a patient’s overall health with over 70 markers. The flagship tests we use with Great Plains are: Great Plains Organic Acids Test (OAT)
The Great Plains Laboratory in the US is a research-based clinical laboratory and world leader in providing diagnostics for metabolic, nutritional, toxic, mitochondrial, and environmental factors in chronic conditions such as autism spectrum disorders, attention deficit disorders, fibromyalgia, mould illness, chemical exposure and related illnesses, and gastrointestinal and neuropsychiatric disorders.